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William Plunkett Selected Research

Phosphotransferases (Kinase)

1/2021The multi-kinase inhibitor TG02 induces apoptosis and blocks B-cell receptor signaling in chronic lymphocytic leukemia through dual mechanisms of action.
1/2008Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine.

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William Plunkett Research Topics

Disease

32Neoplasms (Cancer)
11/2023 - 01/2002
30B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
01/2022 - 02/2002
23Leukemia
01/2021 - 02/2002
21Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2019 - 02/2002
8Hematologic Neoplasms (Hematological Malignancy)
01/2018 - 12/2003
7Myelodysplastic Syndromes (Myelodysplastic Syndrome)
08/2012 - 10/2003
6BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
04/2014 - 10/2003
6Ataxia Telangiectasia (Louis Bar Syndrome)
08/2011 - 08/2006
5Pancreatic Neoplasms (Pancreatic Cancer)
11/2019 - 06/2005
4Chromosome Aberrations (Chromosome Abnormalities)
12/2019 - 08/2005
4Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
06/2014 - 10/2003
2B-Cell Lymphoma (Lymphoma, B Cell)
01/2019 - 10/2005
2Lung Neoplasms (Lung Cancer)
11/2017 - 01/2017
2Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
12/2016 - 08/2010
2Residual Neoplasm
01/2016 - 03/2011
2Adenocarcinoma
04/2014 - 09/2003
2Blast Crisis (Blast Phase)
08/2012 - 02/2005
2Lymphoma (Lymphomas)
06/2005 - 01/2002
1Pancreatic Cyst
11/2019
1Inflammation (Inflammations)
11/2019
1Metaplasia
11/2019
1Neoplasm Metastasis (Metastasis)
11/2019
1Carcinogenesis
11/2019
1Obesity
11/2019
1Ovarian Neoplasms (Ovarian Cancer)
01/2018
1Hyperbilirubinemia
11/2017
1Exanthema (Rash)
11/2017
1Hypersensitivity (Allergy)
11/2017
1Disease Progression
02/2015
1Hematologic Diseases (Blood Diseases)
02/2015
1Diarrhea
06/2014
1Genetic Translocation (Chromosomal Translocation)
04/2014

Drug/Important Bio-Agent (IBA)

17fludarabineIBA
12/2021 - 01/2002
16Cytarabine (Cytosar-U)FDA LinkGeneric
01/2018 - 10/2002
15Clofarabine (Clolar)FDA Link
01/2018 - 03/2003
14NucleosidesIBA
01/2019 - 09/2002
13DNA (Deoxyribonucleic Acid)IBA
12/2019 - 01/2002
92'- cyano- 2'- deoxyarabinofuranosylcytosineIBA
12/2019 - 08/2005
8GemcitabineFDA Link
11/2014 - 02/2002
7Proteins (Proteins, Gene)FDA Link
01/2019 - 10/2005
6Rituximab (Mabthera)FDA Link
12/2021 - 06/2005
6Cyclophosphamide (Cytoxan)FDA LinkGeneric
12/2021 - 02/2002
6sapacitabineIBA
01/2018 - 01/2010
6ProdrugsIBA
01/2018 - 02/2002
6triphosphoric acid (triphosphate)IBA
03/2008 - 10/2002
5Antineoplastic Agents (Antineoplastics)IBA
02/2010 - 05/2003
4MicroRNAs (MicroRNA)IBA
12/2016 - 10/2007
4Oxaliplatin (Eloxatin)FDA LinkGeneric
10/2013 - 12/2006
47-hydroxystaurosporine (UCN 01)IBA
05/2007 - 02/2002
3Cyclin-Dependent Kinases (cdk Proteins)IBA
01/2022 - 05/2009
3venetoclaxIBA
01/2022 - 01/2019
3ibrutinibIBA
12/2021 - 01/2019
3Arabinofuranosylcytosine TriphosphateIBA
01/2018 - 10/2002
3Messenger RNA (mRNA)IBA
09/2013 - 10/2005
3DNA-Activated Protein KinaseIBA
08/2011 - 01/2008
3N- (5- (((5- (1,1- dimethylethyl)- 2- oxazolyl)methyl)thio)- 2- thiazolyl)- 4- piperidinecarboxamideIBA
08/2010 - 05/2009
3CladribineFDA LinkGeneric
07/2006 - 10/2002
2Apoptosis Regulatory ProteinsIBA
01/2022 - 01/2021
2Phosphotransferases (Kinase)IBA
01/2021 - 01/2008
2Agammaglobulinaemia Tyrosine KinaseIBA
01/2019 - 12/2016
2Purine NucleosidesIBA
01/2018 - 11/2017
2Idarubicin (4 Demethoxydaunorubicin)FDA LinkGeneric
01/2018 - 11/2017
2Transaminases (Aminotransferases)IBA
11/2017 - 06/2014
2Ligases (Synthetase)IBA
01/2016 - 04/2009
2alvocidib (flavopiridol)IBA
02/2015 - 10/2005
2HomoharringtonineIBA
04/2014 - 01/2011
2bcr-abl Fusion ProteinsIBA
04/2014 - 11/2006
2Ribonucleotide Reductases (Ribonucleotide Reductase)IBA
09/2013 - 12/2003
2DeoxycytidineIBA
08/2012 - 01/2010
2NK314IBA
08/2011 - 05/2007
2ChromatinIBA
12/2010 - 01/2008
2rabacfosadineIBA
06/2009 - 05/2008
2NucleotidesIBA
06/2009 - 05/2008
2nelarabine (506U78)FDA Link
03/2008 - 11/2006
2Alkylating AgentsIBA
09/2007 - 02/2002
2Mitochondrial DNA (mtDNA)IBA
12/2006 - 09/2003
2Free RadicalsIBA
09/2003 - 05/2003
1CYC065IBA
01/2022
1RNA Polymerase II (RNA Polymerase B)IBA
01/2022
1obinutuzumabIBA
12/2021
114- methyl- 20- oxa- 5,7,14,26- tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa- 1(25),2(26),3,5,8(27),9,11,16,21,23- decaeneIBA
01/2021
1TrabectedinIBA
12/2019
1fibroblast growth factor 21IBA
11/2019
1Triglycerides (Triacylglycerol)IBA
11/2019
1Poly(ADP-ribose) Polymerase InhibitorsIBA
01/2018
1Drug CombinationsIBA
01/2018
1Taxoids (Taxanes)IBA
01/2018
1Platinum Compounds (Compounds, Platinum)IBA
01/2018
12- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA
11/2017
1Histone Deacetylase InhibitorsIBA
01/2016
1Histone Deacetylases (Histone Deacetylase)IBA
01/2016
1Arginine (L-Arginine)FDA Link
06/2015
1Cyclin-Dependent Kinase 9IBA
02/2015
1Nucleoside Transport Proteins (Nucleoside Transporter)IBA
04/2014
1triciribine phosphateIBA
11/2013

Therapy/Procedure

20Therapeutics
11/2023 - 02/2002
7Drug Therapy (Chemotherapy)
01/2017 - 06/2005
2Intravenous Infusions
02/2005 - 12/2003
1Immunomodulation
12/2019
1Injections
11/2019